Recent Publications

Putnins, E.E. and Bowden, G.H. (1993). Antigenic relationships between oral Actinomyces isolates, Actinomyces naeslundii genospecies 1 and 2, Actinomyces howellii, Actinomyces denticolens and Actinomyces slackii. J. Dent. Res. 72:1374-1385.

Putnins, E.E., Firth, J.D. and Uitto, V.-J. (1996). Stimulation of collagenase (MMP-1) synthesis in histiotypic epithelial cell culture by heparin and heparan sulfate with further stimulation by KGF. Matrix Biology, 15:21-29.

Häkkinen L, Kainulainen T, Salo T, Sheppard D, Larjava H. Expression of integrin α9 subunit and tenascin in oral leukoplakia, lichen planus, and squamous cell carcinoma. Oral Diseases, 5:210-217, 1999.

Koivisto L, Larjava K, Häkkinen L,, Uitto V-J, Heino J, Larjava H. Different integrins mediate cell spreading, haptotaxis and lateral migration of HaCaT keratinocytes on fibronectin. Cell Adhes Commun, 7:245-257, 1999.

Putnins, E.E., Firth, J.D., Lohachitranont, A., Uitto, V.-J. and Larjava, H. (1999). Keratinocyte Growth Factor (KGF) Promotes Keratinocyte Cell Attachment and Migration on Collagen and Fibronectin. Cell Adhes. Commun. 7(3):211-221.

Ravanti L, Häkkinen L, Larjava H, Saarialho-Kere U, Fischi M, Han J, Kähäri V-M. Transforming growth factor-β induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase. J Biol Chem, 274:37292-37300, 1999.

Häkkinen L, Hildenbrand HC, Berndt A, Kosmehl H, Larjava H. Immunolocalization of tenascin-C, α9 integrin subunit and αvβ6 integrin during wound healing in human oral mucosa. J Histochem Cytochem, 48:985-998, 2000.

Häkkinen L, Strassburger S, Scott P, Kähäri V-M, Eichstetter I, Iozzo RV, Larjava H. A Role for Decorin in the Structural Organization of Periodontal Ligament. Lab Invest, Invest, 80:1869-80, 2000.

Putnins, E.E., Di Giovanni, D. and Bhullar, A. (2001). Dental Unit Waterline Contamination and Its Possible Implications During Periodontal Surgery. Journal of Periodontology 72:393-400.

Ghersi G, Dong H., Goldstein LA, Yeh Y, Häkkinen L, Larjava HS, Chen W-T. Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex. J Biol Chem, 277:29231-29241, 2002.

Häkkinen L, Koivisto L, Larjava H. An improved method for culture of epidermal keratinocytes from newborn mouse skin. Methods in Cell Science, 23:189-196, 2002.

Hildebrand HC, Häkkinen L, Wiebe C, Larjava H. Characterization of organotypic keratinocyte cultures on de-epithelialized tongue mucosa. Histology & Histopathology, 17:151-163, 2002.

Sanaie, A.R., Firth, J.D., Uitto, V.J., Putnins, E.E. (2002). Keratinocyte Growth Factor (KGF)-1 and -2 Protein and Gene Expression in Human Gingival Fibroblasts. Journal of Periodontal Research 37(1):66-74, 2002.

Putnins, E.E., Sanaie, A.R., Wu, Q. and Firth, J.D. (2002). Induction of Keratinocyte Growth Factor-1 Expression by Lipopolysaccharide is Regulated by CD14 and Toll-like Receptors 2 and 4. Infection and Immunity, 70(12):6541-6548.

Wiebe CB, Penagos H, Luong N, Slots J, Epstein E Jr, Siegel D, Häkkinen L, Putnins EP, Larjava HS. Clinical and microbiologic study of periodontitis associated with kindler Syndrome. J Periodontol, 74:25-31, 2003.

Koivisto L, Alavian K, Häkkinen L, McCulloch CA, Larjava H. Glycogen synthase kinase-3 regulates extended lamellipodia formation in human keratinocytes. J Cell Science, 116:3749-3760, 2003.

Impola U, Uitto V-J, Hietanen J, Häkkinen L, Zhang L , Larjava H, and Saarialho-Kere U. Differential expression of matrilysin-1 (MMP-7), 92 kDa gelatinase (MMP-9) and metalloelastase (MMP-12) in oral verrucous and squamous cell cancer. J. Pathol, 202:14-22, 2004.

Häkkinen L, Koivisto L, Gardner H, Saarialho-Kere, U, Carroll J, Lakso M, Heino J, Larjava, H. Increased expression of beta-6 integrin in skin leads to spontaneous development of chronic wounds. Am J Pathol, 164:229-242, 2004.

Koivisto L, Häkkinen L, Matsumoto K, McCulloch CA, Yamada K, Larjava H. Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions in human keratinocytes. Exp Cell Res, 293:68-80, 2004.

Firth, J.D. and Putnins, E.E. (2004) Keratinocyte Growth Factor-1 Inhibits Wound Edge Epithelial Cell Apoptosis in Vitro. Journal of Investigative Dermatology, 122(1):222-231.

Jokinen J, Dadu E, Nykvist P, Käpylä J, White DJ, Ivaska J, Vehviläinen P, Reunanen H, Larjava H, Häkkinen L, Heino J. Integrin-mediated cell adhesion to type 1 collagen fibrils. J Biol Chem, 279:31956-31963, 2004.

Alimohamad H, Habijanac T, Larjava H, Häkkinen L. Colocalization of the collagen-binding proteoglycans decorin, biglycan, fibromodulin, and lumican with different cells in human gingiva. J Periodont Res, 40:73-86, 2005.

Matheson S, Larjava H, Häkkinen L. Distinctive localization and function for lumican, fibromodulin and decorin to regulate collagen fibril organization in periodontal tissues. J Periodont Res, 40:312-324, 2005.

Leivonen S-K, Häkkinen L, Liu D, Kähäri V-M. Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-ß-induced expression of connective tissue growth factor in human fibroblasts. J Invest Dermatol, 124:1162-1169, 2005.

Bhide VM, Laschinger CA, Arora PD, Lee W, Häkkinen L, Larjava H, Sodek J, McCulloch CAG. Collagen phagocytosis by fibroblasts is regulated by decorin. J Biol Chem, 280:23103-23113, 2005.

Tsang P, Derkson G, Priddy R, Junker AK, Slots J, Larjava H. Severe periodontitis in a 5-year-old girl with hyperimmunoglobulin E syndrome. Pediatr Dent 27:68-73, 2005.

Aldahlawi S, Eslami A, Häkkinen L, Larjava H. The avb6 integrin plays a role in compromised epidermal wound healing. Wound Repair Regen 14:289-297, 2006.

Honardoust D, Jiang G, Koivisto L, Wienke D, Isacke C, Larjava H, Häkkinen L. Expression of Endo180 is spatially and temporally regulated in distinct cells during wound healing. Histopathology 49:634-648, 2006.

Koivisto L, Jiang G, Häkkinen L, Chan B, Larjava H. HaCaT keratinocyte migration is dependent on epidermal growth factor receptor signaling and glycogen synthase kinase-3alpha. Exp Cell Res 15:2791-2805, 2006.

Walsh P, Häkkinen L, Pernu H, Larjava H. Integrin expression in drug-induced gingival overgrowth. J Periodontal Res 42:144-151, 2007.

Csiszar A, Wiebe C, Larjava H, Häkkinen L. Distinct molecular composition of human interdental papilla. J Periodontol, 78:304-314, 2007.

Narani N, Owen GRh, Häkkinen L, Putnins E, Larjava H. Enamel matrix proteins bind to wound provisional matrix proteins and regulate their cell adhesive properties. Eur J Oral Sci. 115:288-95, 2007.

Häkkinen L, Csiszar A. Hereditary gingival fibromatosis: Characteristics and novel putative pathogenic mechanisms. J Dent Res 86:25-34, 2007.

Papachristou DJ, Gkretsi V, Tu Y, Shi X, Chen K, Larjava H, Rao UN, Wu C. Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma. Histopathology, 51:499-508, 2007.

Wiebe CB, Petricca G, Häkkinen L, Jiang G, Wu C, Larjava HS. Kindler syndrome and periodontal disease: Review of the literature and 12-year follow-up of treatment outcome. J Periodontol, J Periodontol, 79:961-966, 2008.

Ghannad F, Nica D, Garcia MI, Grenier D, Johnston S, Eslami A, Koivisto L, Putnins EE, Jiang G, McKee MD, Häkkinen L, Larjava H. Absence of avb6 integrin is linked to initiation and progression of periodontal disease. Am J Pathol, 172:1271-1286, 2008.

Honardoust D, Eslami A, Larjava H, Häkkinen L. Localization of Small Leucine-Rich Proteoglycans and Transforming Growth Factor-b in human oral mucosal wound healing. Wound Repair Regen, 16:814-823, 2008.

Larjava H, Plow EF, Wu C. Kindlins: essential regulators of integrin signaling and cell-matrix adhesion. EMBO Rep, 2008 12:1203-1208.

Eslami A, Gallant-Behm C, Hart D, Wiebe C, Honardoust D, Gardner H, Häkkinen L, Larjava HS. Expression of Integrin avb6 and TGF-b in Scar-free vs. Scar-forming Wound Healing. J Histochem Cytochem, 57:543-557, 2009.

Xie Y, Gao K, Häkkinen L, Larjava H. Loss of b6 integrin partially ameliorates dexamethasone-impaired cutaneous wound healing. Wound Repair Regen, 17:326-329, 2009.

Petricca G, Leppilampi M, Jiang G, Owen GRh, Wiebe C, Tu Y, Koivisto L, Häkkinen L, Wu C, Larjava H. Kindlin-1 interacts with migfilin and supports keratinocyte adhesion, proliferation and migration. Eur J Oral Sci, 117:516-527, 2009.

Wong JW, Gallant-Behm C, Wiebe C, Mak K, Hart DA, Larjava H, Häkkinen L. Wound healing in oral mucosa results in reduced scar formation as compared to skin: Evidence from the red Duroc pig model and humans. Wound Repair Regen, 17:717-729, 2009.

Mak K, Manji A, Gallant-Behm CL, Wiebe C, Hart DA, Larjava H, Häkkinen L. Scarless healing of oral mucosa is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model. J Dermatol Sci, 56:168-180, 2009.

Owen GRh, Häkkinen L, Wu C, Larjava H. Labeling antigens using preformed fluorescent molecular IgG-F(ab’)2 complexes from primary antibodies of the same species. Microsc Res Technique, in press, 2009.

Review Articles & Book Chapters

Larjava H, Koivisto L, Häkkinen L. Keratinocyte interaction with fibronectin during wound healing. In Cell Invasion (Heino J, Kähäri V-M, eds.). Landes Biosciences,, Georgetown, TX, 2000.

Häkkinen L, Uitto V-J, Larjava H. Cell Biology of Gingival Wound Healing. Periodontology 2000, 24:127-152, 2000.

Steffensen B, Häkkinen L, Larjava H. Proteolytic events of wound healing – Coordinated interactions between matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules. Crit Rev Oral Biol Med, 12:373-398, 2001.

Putnins, E.E. (2001) Keratinocyte Growth Factor (KGF): Its Possible Use in Tissue Engineering. In: Cultured Human Keratinocytes and Tissue Engineered Skin Substitutes – State of the Art. R.E. Horch, A.M. Munster and B. Achauer, Editors, pp. 129-138.

Ghersi G, Dong H, Goldstein LA, Yeh Y, Häkkinen L, Larjava HS, Chen W-T. Seprase-DPPIV association and prolyl peptidase and gelatinase activities of the protease complex. Advances in Experimental Medicine & Biology, 524:87-94, 2003.