Dr. Brunette’s Research

Post Secondary Education:

B.Sc. Chemistry 1966 University of Toronto
M.Sc. Medical Biophysics 1968 University of Toronto
Ph.D. Medical Biophysics 1972 University of Toronto



  • ORBI 430 Understanding and Evaluating Dental Research (Undergraduate)
  • ORBI 500 Research Methods in Oral Biology (Graduate)


  • 1968-1972
    National Cancer Institute Fellow
  • 1980
    International Association for Dental Research: Basic Research in Oral Science Award
  • 1993
    W.W. Wood Award for Excellence in Dental Education
  • 1993
    Honourary Professor, China Medical University

Research Interests:

  • Regulation of cell behaviour on implant surfaces by substratum topography
  • Oral malodour
  • Citation analysis

Current Grant Support:

  • Medical Research Council of Canada Operating Grant “Regulation of cell behaviour by surface topography”.
  • Medical Research Council of Canada Maintenance Grant “Maintenance grant for electron and confocal microscope facility”.
  • Church and Dwight (Arm and Hammer) “Oral Malodour”.
  • The University of British Columbia University Industry Liaison Office “Prototype production”.

Past Grant Support:

  • British Columbia Health Research Foundation
  • National Institute of Dental Research (USA)
  • Vipont Pharmaceuticals


  • International Journal of Oral and Maxillofacial Implants
  • Church and Dwight

Service on Review Committees:

  • Medical Research Council of Canada (Dental Sciences, Fellowships, Site Visits)
  • British Columbia Health Research Foundation (New Investigators, Established Investigators)
  • Ontario Centre for Materials Research
  • Commission of Dental Accreditation (Canada) (Site Visits)

Theses Supervised/Co-supervised

  • 6 Ph.D.
  • 6 M.Sc.

External Examiner:

Ph.D. Theses: University of Toronto, University of Manitoba, McGill University, Royal College of Dentists Fellowship


Critical thinking: Understanding and evaluating dental research”. D.M. Brunette, Quintessence, Carol Stream, IL, 1996.

Book Chapters

Refereed Publications


Key Articles

Brunette, D.M. and Till, J.E. A rapid method for the isolation of L-cell surface membranes using an aqueous two phase polymer system”, J. Membrane Biol. 5:215-224, 1971.

Baker, R.M., Brunette, D.M., Mankovitz, R., Thompson, L.H., Whitemore, G.F., Simonovitch, L. and Till, J.E. Oubain-resistant mutants of mouse and hamster cells in culture”, Cell 1:9-21, 1974.

Brunette, D.M., Melcher, A.H. and Moe, H.K. Culture and origin of epithelial-like and fibroblast-like cells from porcine periodontal ligament explants and cell suspensions”, Arch. Oral Biol. 21:393-400, 1976.

Gould, T.R.L., Brunette, D.M. and Westbury, L. “The attachment mechanism of epithelial cells to titanium in vitro”, J. Perio. Res. 16:611-616, 1981.

Boyko, G.A., Melcher, A.H. and Brunette, D.M. “Formation of new periodontal ligament by periodontal ligament cells implanted in vivo after culture in vitro“, J. Perio. Res. 16:73-88, 1981.

Brunette, D.M., Kenner, G.S. and Gould, T.R.L. “Grooved titanium surfaces orient growth and migration of cells from human gingival explants”, J. Dent. Res. 62:1045-1048, 1983.

Brunette, D.M. Mechanical stretching increases the number of epithelial cells synthesizing DNA in culture”, J. Cell Science 69:35-45, 1984.

Brunette, D.M. “Fibroblasts on micromachined substrata orient hierarchically to grooves of different dimensions”, Exp. Cell Res. 164:11-26, 1986.

Brunette, D.M. “The effects of surface topography on the behaviour of cells on implants”, Int. J. of Oral Maxilliofacial Implantology”, 3:231-246, 1988.

Chehroudi, B., Gould, T.R.L. and Brunette, D.M. “The role of connective tissue in inhibiting epithelial downgrowth on titanium-coated percutaneous implants”, J. Biomedical Materials Res., 26:493-515, 1992.

Oakley, C. and Brunette, D.M. “Topographic compensation: guidance and directed locomotion of fibroblasts on grooved micromachined substrata in the absence of microtubules”, Cell Motility and the Cytoskeleton, 31:45-58, 1995.

Brunette, D.M. Effects of baking soda containing dentifrices on oral malodour” Compendium of Continuing Education in Dentistry, S19:522-532, 1996.